|
|
@@ -548,6 +548,57 @@
|
|
|
margin: 1.25rem 0;
|
|
|
}
|
|
|
.shot-placeholder .shot-icon { font-size: 2.2rem; opacity: 0.35; }
|
|
|
+ .ref-shot { width:100%; max-width:720px; border-radius:8px; box-shadow:0 2px 8px rgba(0,0,0,0.1); margin:1.25rem 0; display:block; }
|
|
|
+ .evidence-inline {
|
|
|
+ margin: 1.5rem 0;
|
|
|
+ padding: 1rem;
|
|
|
+ background: #f8fafc;
|
|
|
+ border: 1px solid #e2e8f0;
|
|
|
+ border-radius: 16px;
|
|
|
+ box-shadow: 0 4px 24px rgba(0,0,0,0.08);
|
|
|
+ }
|
|
|
+ .evidence-inline .evidence-title {
|
|
|
+ font-size: 0.9rem;
|
|
|
+ font-weight: 600;
|
|
|
+ margin-bottom: 0.6rem;
|
|
|
+ display: flex;
|
|
|
+ align-items: center;
|
|
|
+ gap: 0.4rem;
|
|
|
+ }
|
|
|
+ .evidence-inline .evidence-image-wrap {
|
|
|
+ position: relative;
|
|
|
+ display: inline-block;
|
|
|
+ max-width: 100%;
|
|
|
+ border-radius: 8px;
|
|
|
+ overflow: hidden;
|
|
|
+ border: 1px solid #e2e8f0;
|
|
|
+ }
|
|
|
+ .evidence-inline .evidence-image-wrap img {
|
|
|
+ display: block;
|
|
|
+ max-width: 100%;
|
|
|
+ height: auto;
|
|
|
+ max-height: 220px;
|
|
|
+ }
|
|
|
+ .evidence-inline .evidence-caption {
|
|
|
+ margin-top: 0.75rem;
|
|
|
+ font-size: 0.85rem;
|
|
|
+ line-height: 1.6;
|
|
|
+ }
|
|
|
+ .evidence-inline .evidence-translation {
|
|
|
+ margin-top: 0.5rem;
|
|
|
+ padding: 0.5rem 0.7rem;
|
|
|
+ background: #f0f7ff;
|
|
|
+ border-left: 3px solid #2d7d9a;
|
|
|
+ border-radius: 0 6px 6px 0;
|
|
|
+ font-size: 0.82rem;
|
|
|
+ }
|
|
|
+ .evidence-inline .evidence-meta {
|
|
|
+ margin-top: 0.6rem;
|
|
|
+ font-size: 0.8rem;
|
|
|
+ color: #718096;
|
|
|
+ }
|
|
|
+ .evidence-inline .evidence-meta a { color: #2d7d9a; }
|
|
|
+ .evidence-inline .evidence-meta a:hover { text-decoration: underline; }
|
|
|
</style>
|
|
|
</head>
|
|
|
<body>
|
|
|
@@ -653,10 +704,18 @@
|
|
|
</div>
|
|
|
</div>
|
|
|
|
|
|
- <div class="shot-placeholder">
|
|
|
- <div class="shot-icon">🧬</div>
|
|
|
- <span>../img/ref-screenshots/cancer_ref1.png</span>
|
|
|
- </div>
|
|
|
+ <div class="evidence-inline">
|
|
|
+ <div class="evidence-title">📊 全球癌症负担数据 — CA Cancer Statistics 2022</div>
|
|
|
+ <div class="evidence-caption">
|
|
|
+ <strong>CA: A Cancer Journal for Clinicians 2022:</strong> 全球新发癌症病例1929万、死亡996万。中国新发457万、死亡300万,均为世界第一。肺癌、结直肠癌、胃癌、肝癌、乳腺癌为前五大癌种。
|
|
|
+ </div>
|
|
|
+ <div class="evidence-translation">
|
|
|
+ 📖 中文翻译:全球癌症负担持续增长,中国新发病例占全球24%,死亡占30%——相当于每10秒就有一人被确诊癌症。早期筛查和生活方式干预是降低癌症死亡率最有效的手段。
|
|
|
+ </div>
|
|
|
+ <div class="evidence-meta">
|
|
|
+ 来源:Sung H et al. "Global Cancer Statistics 2020" · <a href="https://doi.org/10.3322/caac.21660" target="_blank" rel="noopener">doi:10.3322/caac.21660</a>
|
|
|
+ </div>
|
|
|
+</div>
|
|
|
|
|
|
<div class="evidence-box" style="margin-top:2rem;">
|
|
|
<div class="evidence-box-header">
|
|
|
@@ -925,10 +984,18 @@
|
|
|
<p><strong>临床转化:</strong>肠道菌群还可影响免疫检查点抑制剂(如PD-1/PD-L1抗体)的治疗效果——对免疫治疗有响应的患者肠道菌群中Akkermansia muciniphila和Ruminococcaceae的丰度显著更高。抗生素暴露会降低免疫治疗的治疗效果。</p>
|
|
|
</div>
|
|
|
|
|
|
- <div class="shot-placeholder">
|
|
|
- <div class="shot-icon">🧬</div>
|
|
|
- <span>../img/ref-screenshots/cancer_ref2.png</span>
|
|
|
- </div>
|
|
|
+ <div class="evidence-inline">
|
|
|
+ <div class="evidence-title">🧬 癌症十大特征 — Hallmarks of Cancer</div>
|
|
|
+ <div class="evidence-caption">
|
|
|
+ <strong>Cell 2011, Hallmarks of Cancer: The Next Generation:</strong> Hanahan & Weinberg 提出癌症十大特征:自给自足生长信号、抗生长信号不敏感、抵抗细胞死亡、无限复制潜能、持续血管生成、组织侵袭转移、免疫逃逸、促肿瘤炎症、基因组不稳定、能量代谢重编程。
|
|
|
+ </div>
|
|
|
+ <div class="evidence-translation">
|
|
|
+ 📖 中文意义:癌症绝不是单一疾病,而是涉及多条信号通路、多种微环境改变的复杂系统性疾病。这解释了为什么单一靶点药物容易耐药——从多维度(炎症、代谢、免疫、肠道菌群)同时干预才是治本之道。
|
|
|
+ </div>
|
|
|
+ <div class="evidence-meta">
|
|
|
+ 来源:Hanahan D, Weinberg RA. "Hallmarks of Cancer: The Next Generation" · <a href="https://doi.org/10.1016/j.cell.2011.02.013" target="_blank" rel="noopener">doi:10.1016/j.cell.2011.02.013</a>
|
|
|
+ </div>
|
|
|
+</div>
|
|
|
|
|
|
<div class="process-steps" style="margin-top:1rem;">
|
|
|
<div class="process-step">
|
|
|
@@ -986,10 +1053,18 @@
|
|
|
</div>
|
|
|
<p style="color:var(--text-muted);font-size:0.82rem;margin-bottom:1.5rem;">参考:《中国癌症筛查指南》2023 · 国家癌症中心</p>
|
|
|
|
|
|
- <div class="shot-placeholder">
|
|
|
- <div class="shot-icon">🧬</div>
|
|
|
- <span>../img/ref-screenshots/cancer_ref3.png</span>
|
|
|
- </div>
|
|
|
+ <div class="evidence-inline">
|
|
|
+ <div class="evidence-title">🧬 遗传性癌症易感基因筛查指南 — JCO 2021</div>
|
|
|
+ <div class="evidence-caption">
|
|
|
+ <strong>Journal of Clinical Oncology 2021:</strong> ASCO/AHC 指南建议对符合家族史标准的癌症患者进行多基因胚系突变检测。BRCA1/2、MLH1/MSH2(林奇综合征)、TP53(Li-Fraumeni)等基因突变携带者患癌风险显著升高。
|
|
|
+ </div>
|
|
|
+ <div class="evidence-translation">
|
|
|
+ 📖 中文意义:约5-10%的癌症由遗传易感基因突变引起。携带者并非一定会患癌,但需要更早期、更频繁的专项筛查。家族中有多位年轻癌症患者、或同一人患多种原发癌时,建议进行遗传咨询和基因检测。
|
|
|
+ </div>
|
|
|
+ <div class="evidence-meta">
|
|
|
+ 来源:Daly MB et al. "Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic" · <a href="https://doi.org/10.1200/JCO.20.02299" target="_blank" rel="noopener">doi:10.1200/JCO.20.02299</a>
|
|
|
+ </div>
|
|
|
+</div>
|
|
|
|
|
|
<div class="grid-2" style="margin-bottom:1.5rem;">
|
|
|
<div>
|
|
|
@@ -1113,10 +1188,21 @@
|
|
|
</div>
|
|
|
</div>
|
|
|
|
|
|
- <div class="shot-placeholder">
|
|
|
- <div class="shot-icon">🧬</div>
|
|
|
- <span>../img/ref-screenshots/cancer_ref4.png</span>
|
|
|
- </div>
|
|
|
+ <div class="evidence-inline">
|
|
|
+ <div class="evidence-title">🦠 肠道菌群与结直肠癌 — Science 2015</div>
|
|
|
+ <div class="evidence-image-wrap">
|
|
|
+ <img src="../img/gut-microbiome-damage.jpg" alt="Colorectal cancer - Fusobacterium nucleatum and gut microbiota" style="max-height:200px;">
|
|
|
+ </div>
|
|
|
+ <div class="evidence-caption">
|
|
|
+ <strong>Science 2015:</strong> Fusobacterium nucleatum(具核梭杆菌)在结直肠癌组织中富集,可通过FadA黏附素结合E-cadherin激活β-catenin信号通路,促进癌细胞的增殖和肿瘤进展。
|
|
|
+ </div>
|
|
|
+ <div class="evidence-translation">
|
|
|
+ 📖 中文意义:口腔中的条件致病菌——具核梭杆菌,竟然能通过血液循环到达肠道并直接促进结直肠癌的发展。这揭示了口腔-肠道-癌症的微生物通路。维护口腔菌群健康、促进肠道微生态平衡,可能是预防结直肠癌的重要策略。
|
|
|
+ </div>
|
|
|
+ <div class="evidence-meta">
|
|
|
+ 来源:Rubinstein MR et al. "Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling" · <a href="https://doi.org/10.1016/j.chom.2013.07.012" target="_blank" rel="noopener">doi:10.1016/j.chom.2013.07.012</a>
|
|
|
+ </div>
|
|
|
+</div>
|
|
|
|
|
|
<!-- STEP 04 -->
|
|
|
<h3 style="font-size:1.15rem;font-weight:700;margin:2rem 0 1rem;color:var(--orange);">④ 筛查追踪——用数据验证预防是否有效</h3>
|